Pharmacokinetics of Florfenicol via Nanosuspersion after Oral Administration to Rabbits

The purpose of this study was to evaluate the pharmacokinetic behavior of florfenicol spray-dried nanosuspersion after oral administration to rabbits and to compare its oral bioavailability characteristics to that of a known soluble powder. Florfenicol spray-dried nanosuspersion was produced by high pressure homogenization followed by spray drying. Plasma concentrations were determined by HPLC. When administered at equal doses, the area under the plasma concentration (AUC 0–∞) of florfenicol following intragastric administration of the spray-dried nanosuspersion and soluble powder were 36.02±5.49 μg· h· mL -1 and 29.35±4.65 μg· h· mL -1 ; the C max was 9.83±1.22 μg/mL and 9.00±1.61 μg/mL; the T1/2 were 2.95± 0.81 h and 3.08± 0.83 h, respectively. We conclude that the oral bioavailability of spray-dried nanosuspersion was 1.26-fold higher than that of soluble powder. Based upon the results of this investigation, the florfenicol spray dried nanosuspersion is a viable potentially veterinary preparation for the oral administration.